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KMID : 0191120220370150116
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Journal of Korean Medical Science
2022 Volume.37 No. 15 p.116 ~ p.116
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Autoimmune Hepatitis Following Vaccination for SARS-CoV-2 in Korea: Coincidence or Autoimmunity?
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Kang Seong-Hee
Kim Moon-Young
Cho Mee-Yon
Baik Soon-Koo
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Abstract
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Autoimmune hepatitis (AIH) is a chronic, autoimmune disease of the liver that occurs when the body’s immune system attacks liver cells, causing the liver to be inflamed. AIH is one of the manifestations of a coronavirus disease 2019 (COVID-19), as well as an adverse event occurring after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Few cases of AIH have been described after vaccination with two messenger RNA (mRNA)-based vaccines?BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)?against SARS-CoV-2. Herein, we report a case of AIH occurring after Pfizer-BioNTech COVID-19 vaccine. A 27-year-old female presented with jaundice and hepatomegaly, appearing 14 days after receiving the second dose of Pfizer-BioNTech vaccine. Her laboratory results showed abnormal liver function with high total immunoglobulin G level. She was diagnosed with AIH with histologic finding and successfully treated with oral prednisolone. We report an AIH case after COVID-19 vaccination in Korea.
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KEYWORD
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Coronavirus Disease 2019, Vaccine, Autoimmune Hepatitis
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